Thursday, November 28, 2013

Clinical Research And The Future Of Dementia

By Jack Morgan


With more than 5 million in the U.S and 800,000 people in the U.K currently living with dementia, perhaps it's surprising to find that studies directed towards dementia are massively under-funded. This disease is genetically complex, gradual in action and is irreversible in some cases. And the statistics are set to rise as days go by. So what about research and the future of dementia, does it mean there's nothing researchers in this field can do?

According to the Fight Dementia Organization, there were an estimated 220 050 people living with dementia in 2007 and the figure is expected to escalate to around 465 460 in 2030. As the future of this epidemic is this grim, based on the figures, there is every need to explore the implications of the impetus created by past and current research endeavors in this health domain with special spotlight on the research and the future of dementia.

Although Alzheimer disease is widely associated with dementia clinical conditions, not all dementia patients develop Alzheimer. Some patients may have dementia while never developed Alzheimer. Dementia researches that try to associate Alzheimer usually show a bell shaped result from patients under study.

The only challenge that researchers face is inadequate funding. If, at all, they are going to achieve their ultimate goal, then funding is going to be inevitable. This funding will help support research into neurodegenerative diseases, the risk factors involved, plus many other things that involve dementia.

The observed differences between people who score low in cognitive tests and don't develop dementia poses future research questions. Dementia study is also complicated in a way because it largely depends on memory tests. Age, sex, race and education are also factors that can show differences in cognitive memory tests regardless of whether the patients have developed dementia or not.

Future research endeavors will be underpinned on the ultimate goal of enhancing prevention measures, diagnosis, care and treatment of dementia. Previous researches conducted in this domain have also created a drive for discovery science as well as the use of experimental medicine. This can be implemented in the direction of picking up new targets for therapeutic development. Future work in this discipline will involve developing successful or prospectively successful compounds to advanced level trials.

Future research work is expected to take a more open form that allows integration of research endeavors with public service. This is expected to increase public participation in the core of dementia research as a bid to increase awareness on the diseases while underscoring the role that research plays in stepping up to the challenges of dementia.

Current dementia and Alzheimer management don't take into account the different categories of patients. Sometimes every patient has a unique mental condition and that will require custom management. Mental conditions worsen with age. Therefore, patients are not always of the same age and custom dementia management is justified.

Finally, it is said that some Australian researchers found a possible natural remedy for dementia. They discovered a natural substance in the body cells known as "Spermidine" which they say can aid in memory loss, which is a major concern for patients suffering from dementia. The concentration of spermidine decreases as one gets older. Spermidine was administered to specimen of mammals such as rats and mice because they have similar memory functions to human beings. So they're hoping that the results will be transferred to humans someday in the near future.




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